Qinghaosu: a new antimalarial.

The development of the antimalarial drugs with new type of chemical structure--qinghaosu and dihydroqinghaosu.

A Brief History of Qinghaosu

The 2015 Nobel Prize for Medicine or Physiology was awarded to William C. Campbell and Satoshi Ōmura for their discovery of avermectins, and to Tu You You for her contribution to the discovery of artemisinin. The discovery and development of qinghaosu (artemisinin) as an antimalarial drug is a remarkable and convoluted tale.

Cryptolepine and development of new antimalarial agents

Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...

Cryptolepine and development of new antimalarial agents

Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...

Interaction of biomolecules with qinghaosu (artemisinin) and its derivatives in the presence of ferrous ionÐan exploration of antimalarial mechanism

Yu-Lin Wu,2 Hai-Bao Chen, Kun Jiang, Ying Li, Feng Shan, Dong-Ye Wang, Yan-Fang Wang, Wen-Ming Wu, Yikang Wu, Zhu-Jun Yao, Zheng-Yu Yue and Cheng-Ming Zhou State Key laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200...